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vivacell_graurotbuttonklein  Recent news

September 2016

Cooperation with Dhofar University (Sultanate of Oman)

 

May 2016

We were awarded the Stifterverband's "Innovative through Research" for our research activities.

 

April 2016

New Version of SimDerma including 30 important dermato-cosmetic parameters.

Read more here.

 

November 2015:

New Services in neurotoxicity and neuroprotection

Read more here.

 

October 2015:

SimDerma - new screening platform for cosmetic ingredients.

simderma_werbefoto

Read more here.

 

Services in Oral Care.

Read more here.

 

September 2015:

Please have a look at our new services in miRNA research.

Read more here.

 


 

New publications by VivaCell:

 

"Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary
microglia."

in J Neuroinflamm. 2016 Jan

 

"Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia
Through Nrf2-Dependent Mechanisms."

in Mol Neurobiol. 2015 Nov

 

"microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia."

in J Neurochem, 2015 Sep

 

"Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes."
in Int Immunopharmacol. 2014 Jun

"Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia."
Neuroscience. 2014 Jan 28

 

 

Read more news...

 

 

vivacell_graurotbuttonklein  Opinions from our customers:

p-pascoe-naturmedizin

Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):

:

"During our well going cooperation over several years, we learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."  

 

 

Read more
opinions...

 

 

Phytodrug / Nutraceuticals
Immunomodulation
Cardiovascular inflammation
Oncology / Angiogenesis
Oral care
Central Nervous System
Microglia activation studies
Electrophysiological. Meas.
Dermatology / Cosmetics
Muscle
HIV-1 / AIDS
Diabetes
ADME
Permeability Studies
Toxicology
Urinary / Prostata
Animal health
Additional Services
Quality Certificate
SimDerma / Cosmetics
Neurotox testing / Protection
miRNA
Services in Oral Care

 

We are awarded for our R&D activities by the Stifterverband:

 

forschung_und_entwicklung_2016_web

 

 


 

We are proud members of:

 

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    koop-phyto-logo

ga 

 

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VivaCell Quality-Certificate:

 

vivacellqualitycertificateenglish

 

Read more ...

 

ADME /

DRUG METABOLISM 

  adme organe

 

DRUG METABOLISM (GLP)

Human hepatocytes, rat hepatocytes, microsomes
Cell lines with stable expression of Cytochrome P450-isoenzymes
Cell lines with stable expression of phase II-enzymes (sulfotransferases)

Parameters:
Cytotoxicity (human hepatocytes)
Metabolic stability
Induction (mRNA-level, activity level)
Inhibition (screen, IC50, Ki)

 

P-GLYCOPROTEIN (PGP)
Pgp induction / inhibition assay
Caco-2 cells, LS180 cells
primary bovine brain capillary endothelial cells

Parameters:
Transport activity (rhodamine 123, pgp substrate)
Transport activity (pgp substrate)
Protein level (Western blot)

PHARMACOKINETICS (ADME) <top>


Pharmacokinetic studies with respect to ADME and distribution into organs (rodents).

 

In vivo models:
Rats, mice, guinea pigs, hamsters

 

Parameters:
Individual blood level time profile
Mean blood level time profile 96 h i.v./p.o.
Distribution of radioactivity into cells and plasma
Distribution of radioactive test compound into organs
Excretion of urine, faeces total, excretion into bile
Metabolic pattern by DC

 

 

 

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