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vivacell_graurotbuttonklein  Recent news

September 2016

Cooperation with Dhofar University (Sultanate of Oman)


May 2016

We were awarded the Stifterverband's "Innovative through Research" for our research activities.


April 2016

New Version of SimDerma including 30 important dermato-cosmetic parameters.

Read more here.


November 2015:

New Services in neurotoxicity and neuroprotection

Read more here.


October 2015:

SimDerma - new screening platform for cosmetic ingredients.


Read more here.


Services in Oral Care.

Read more here.


September 2015:

Please have a look at our new services in miRNA research.

Read more here.



New publications by VivaCell:


"Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary

in J Neuroinflamm. 2016 Jan


"Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia
Through Nrf2-Dependent Mechanisms."

in Mol Neurobiol. 2015 Nov


"microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia."

in J Neurochem, 2015 Sep


"Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes."
in Int Immunopharmacol. 2014 Jun

"Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia."
Neuroscience. 2014 Jan 28



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vivacell_graurotbuttonklein  Opinions from our customers:


Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):


"During our well going cooperation over several years, we learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."  



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Phytodrugs / Nutraceuticals
Cancer / Oncology
Recent Publications


We are awarded for our R&D activities by the Stifterverband:






We are proud members of:









VivaCell Quality-Certificate:




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Publications - CNS




Role of prostaglandins in neuroinflammatory and neurodegenerative diseases.

Lima IV, Bastos LF, Limborço-Filho M, Fiebich BL, de Oliveira AC.

Mediators Inflamm. 2012;2012:946813. Epub 2012 Jun 18.   Free PMC Article



The anti-inflammatory effects of the 5-HT(3) receptor antagonist tropisetron are mediated by the inhibition of p38 MAPK activation in primary human monocytes.

Stratz C, Bhatia HS, Akundi RS, Nührenberg T, Trenk D, Muñoz E, Fiebich BL.

Int Immunopharmacol. 2012 Aug;13(4):398-402. Epub 2012 Jun 1.



Micro-array profiling exhibits remarkable intra-individual stability of human platelet micro-RNA.

Stratz C, Nührenberg TG, Binder H, Valina CM, Trenk D, Hochholzer W, Neumann FJ, Fiebich BL.

Thromb Haemost. 2012 Apr;107(4):634-41. Epub 2012 Feb 28.



Molecular targets of the antiinflammatory Harpagophytum procumbens (devil's claw): inhibition of TNFa and COX-2 gene expression by preventing activation of AP-1.

Fiebich BL, Muñoz E, Rose T, Weiss G, McGregor GP.

Phytother Res. 2012 Jun;26(6):806-11. doi: 10.1002/ptr.3636. Epub 2011 Nov 10.


Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia.

de Oliveira AC, Candelario-Jalil E, Langbein J, Wendeburg L, Bhatia HS,

Schlachetzki JC, Biber K, *Fiebich BL*.

J Neuroinflammation. 2012 Jan 3;9:2.PMID:22214188[PubMed - in process]



Pseudoephedrine inhibits T-cell activation by targeting NF-?B, NFAT and AP-1 signaling pathways.

Fiebich BL, Collado JA, Stratz C, Valina C, Hochholzer W, Muñoz E, Bellido LM.

Immunopharmacol Immunotoxicol. 2011 Jun 2


Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?

Straube A, Aicher B, Fiebich BL, Haag G.

BMC Neurol. 2011 Mar 31;11:43. Review.




Endogenous N-acyl-dopamines induce COX-2 expression in brain endothelial cells by stabilizing mRNA through a p38 dependent pathway.

Navarrete CM, Pérez M, de Vinuesa AG, Collado JA, Fiebich BL, Calzado MA, Muñoz E.

Biochem Pharmacol. 2010 Jun 15;79(12):1805-14. Epub 2010 Mar 3.


Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia.

Schlachetzki JC, Fiebich BL, Haake E, de Oliveira AC, Candelario-Jalil E, Heneka MT, Hüll M.

J Neuroinflammation. 2010 Jan 11;7:2.




Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells.

Wendeburg L, de Oliveira AC, Bhatia HS, Candelario-Jalil E, Fiebich BL.

J Neuroinflammation. 2009 Sep 14;6:26.


Opposite effects of anandamide and N-arachidonoyl dopamine in the regulation of prostaglandin E and 8-iso-PGF formation in primary glial cells.

Navarrete CM, Fiebich BL, de Vinuesa AG, Hess S, de Oliveira AC, Candelario-Jalil E, Caballero FJ, Calzado MA, Muñoz E.

J Neurochem. 2009 Apr;109(2):452-64. Epub 2009 Feb 7.



Bhatia HS, Candelario-Jalil E, de Oliveira AC, Olajide OA, Martínez-Sánchez G, Fiebich BL. Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells. Arch Biochem Biophys. 2008 Sep 15;477(2):253-8. Epub 2008 Jun 28.


Candelario-Jalil E, Fiebich BL. Cyclooxygenase inhibition in ischemic brain injury. Curr Pharm Des. 2008;14(14):1401-18. Review.


Moussaieff A, Shein NA, Tsenter J, Grigoriadis S, Simeonidou C, Alexandrovich AG, Trembovler V, Ben-Neriah Y, Schmitz ML, Fiebich BL, Munoz E, Mechoulam R, Shohami E. Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii. J Cereb Blood Flow Metab. 2008 Apr 16;

Candelario-Jalil E, Muñoz E, Fiebich BL. Detrimental effects of tropisetron on permanent ischemic stroke in the rat. BMC Neurosci. 2008 Feb 6;9:19.




Candelario-Jalil E, de Oliveira AC, Gräf S, Bhatia HS, Hüll M, Muñoz E, Fiebich BL. Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia. J Neuroinflammation. 2007 Oct 10;4:25.


Candelario-Jalil E, Taheri S, Yang Y, Sood R, Grossetete M, Estrada EY, Fiebich BL, Rosenberg GA. Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat. J Pharmacol Exp Ther. 2007 Nov;323(2):488-98.


Candelario-Jalil E, González-Falcón A, García-Cabrera M, León OS, Fiebich BL. Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats. J Neurochem. 2007 Feb;100(4):1108-20. Epub 2006 Dec 20.


2006 and before


Candelario-Jalil E, Akundi RS, Bhatia HS, Lieb K, Appel K, Munoz E, Hull M, Fiebich BL. Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E(2) production. J Neuroimmunol. 2006 Mar 8;

Fiebich BL, Candelario-Jalil E, Mantovani M, Heinzmann M, Akundi RS, Hull M, Knorle R, Schnierle P, Finkenzeller G, Aicher B. Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine. Pharmacol Res. 2006 Mar 28;


Yrjänheikki J, Koistinaho J, Kettunen M, Kauppinen R, Appel K, Hüll M, Fiebich BL. Long Term Protective Effect of Atorvastatin in Permanent Focal Cerebral Ischemia. Brain Res. 2005 Aug 9;1052(2):174-9.


Candelario-Jalil E, Mhadu NH, Gonzalez-Falcon A, Garcia-Cabrera M, Munoz E, Leon OS, Fiebich BL. Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat. J Neuroinflammation. 2005 Jan 18;2(1):3.


Candelario-Jalil E, Gonzalez-Falcon A, Garcia-Cabrera M, Leon OS, Fiebich BL.Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat. Brain Res. 2004 May 8;1007(1-2):98-108.

Slawik H, Volk B, Fiebich B, Hull M. Microglial expression of prostaglandin EP3 receptor in excitotoxic lesions in the rat striatum. Neurochem Int. 2004 Oct;45(5):653-60.


Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci. 2001 Apr 15;21(8):2580-8.

References (CNS in vitro)

Akundi RS, Macho A, Munoz E, Lieb K, Bringmann G, Clement HW, Hull M, Fiebich BL. 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline-induced apoptosis in the human neuroblastoma cell line SK-N-SH. J Neurochem. 2004 Oct;91(2):263-73.

Akundi RS, Hull M, Clement HW, Fiebich BL 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) induces apoptosis in human neuroblastoma cell lines. Ann N Y Acad Sci. 2003 Dec;1010:304-6.


Fiebich BL, Lieb K, Kammerer N, Hull M. Synergistic inhibitory effect of ascorbic acid and acetylsalicylic acid on prostaglandin E2 release in primary rat microglia. J Neurochem. 2003 Jul;86(1):173-8.


Lieb K, Treffurth Y, Hamke M, Akundi RS, von Kleinsorgen M, Fiebich BL. Valproic acid inhibits substance P-induced activation of protein kinase C epsilon and expression of the substance P receptor. J Neurochem. 2003 Jul;86(1):69-76.

Sancho, R, Calzado, M.A, DiMarzo, V, Appendino, G, and Muñoz, E. Anandamide inhibits NF-kB activation through a cannabinoid-independent pathway. Molecular Pharmacology.2003 63(2):429-38.


Lieb K, Engels S, Fiebich BL. Inhibition of LPS-induced iNOS and NO synthesis in primary rat microglial cells. Neurochem Int. 2003 Jan;42(2):131-7.

Fiebich BL, Höllig A, Lieb K. Inhibition of substance P-induced cytokine synthesis by St. John’s wort extracts. Pharmacopsychiatry. 2001 Jul;34 Suppl 1:S26-8.

Fiebich BL, Schleicher S, Spleiss O, Czygan M, Hull M. Mechanisms of prostaglandin E2- induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. J Neurochem. 2001 Dec;79(5):950-8.


Fiebich BL, Schleicher S, Butcher RD, Craig A, Lieb K. The neuropeptide substance P activates p38 mitogen-activated protein kinase resulting in IL-6 expression independently from NF-kappa B. J Immunol. 2000 Nov 15;165(10):5606-11.

Fiebich BL, Lieb K, Hull M, Aicher B, van Ryn J, Pairet M, Engelhardt G. Effects of caffeine and paracetamol alone or in combination with acetylsalicylic acid on prostaglandin E(2) synthesis in rat microglial cells. Neuropharmacology. 2000 Aug 23;39(11):2205-13.


Macho, A, Lucena, C, Calzado, M.A, Donnay, I, Appendino, G, Muñoz, E. Phorboid 20- homovanillates induce apoptosis through a VR1-independent mechanism. Chemistry and Biology 2000 7, 483-492





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