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vivacell_graurotbuttonklein  Recent news

September 2016

Cooperation with Dhofar University (Sultanate of Oman)

 

May 2016

We were awarded the Stifterverband's "Innovative through Research" for our research activities.

 

April 2016

New Version of SimDerma including 30 important dermato-cosmetic parameters.

Read more here.

 

November 2015:

New Services in neurotoxicity and neuroprotection

Read more here.

 

October 2015:

SimDerma - new screening platform for cosmetic ingredients.

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Read more here.

 

Services in Oral Care.

Read more here.

 

September 2015:

Please have a look at our new services in miRNA research.

Read more here.

 


 

New publications by VivaCell:

 

"Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary
microglia."

in J Neuroinflamm. 2016 Jan

 

"Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia
Through Nrf2-Dependent Mechanisms."

in Mol Neurobiol. 2015 Nov

 

"microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia."

in J Neurochem, 2015 Sep

 

"Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes."
in Int Immunopharmacol. 2014 Jun

"Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia."
Neuroscience. 2014 Jan 28

 

 

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vivacell_graurotbuttonklein  Opinions from our customers:

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Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):

:

"During our well going cooperation over several years, we learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."  

 

 

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opinions...

 

 

Phytodrug / Nutraceuticals
Immunomodulation
Cardiovascular inflammation
Oncology / Angiogenesis
Oral care
Central Nervous System
Microglia activation studies
Electrophysiological. Meas.
Dermatology / Cosmetics
Muscle
HIV-1 / AIDS
Diabetes
ADME
Permeability Studies
Toxicology
Urinary / Prostata
Animal health
Additional Services
Quality Certificate
SimDerma / Cosmetics
Neurotox testing / Protection
miRNA
Services in Oral Care

 

We are awarded for our R&D activities by the Stifterverband:

 

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We are proud members of:

 

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    koop-phyto-logo

ga 

 

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VivaCell Quality-Certificate:

 

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CENTRAL NERVOUS

SYSTEM

 nervensystem

 

ELECTROPHYSIOLOGICAL MEASUREMENTS


 

Electrophysiological methods are a powerful technology to follow the

activity of ion channels. This methodology has evolved from the

classical measurements using two microelectrodes, to the more sensitive patch-clamp technique that only uses one electrode. Independent of the number of electrodes used, electrophysiological methods may measure both changes in ionic currents under a constant voltage, and variations of the membrane voltage at a constant current.

 

Furthermore, the technique allows monitoring the activity of a

population of channels expressed in a biological membrane, as well as the activity of a single channel molecule. In addition to biophysical

properties of the channel, this technology is also suitable to study ion channel modulation by drug or drug-like compounds that act directly or indirectly on the channel protein. Because of the pivotal roles played by ion channels in physiology and pathology, this technology has remarkably evolved as a sensitive strategy drug discovery platform. In this regard, the heterologous expression of ion channels, along with the highly sensitive patch clamp techniques, has been pivotal to understand the function, dysfunction and pharmacology of these membrane sensors.

 

We offer all methodologies related to patch-clamp on both heterologous expression systems ( Xenopus oocytes, HEK 293, COS, etc.) and primary neuronal cultures (hippocampal neurons and Dorsal Root Ganglion neurons):

 

-Expression of channels in Xenopus oocytes and their electrobiophysical characterization using the two-microelectrode voltage-clamp technology.
-Expression of channels in cell lines and their electrobiophysical characterization using patch-clamp technology, including whole cell and single channel measurements.
-Effect of compounds on the electrophysiological properties of ion channels expressed in recombinant systems or in primary neuronal cultures.
-Effect of compounds on the electrophysiological properties of biological membranes of primary neuronal cultures, i.e. effect on membrane resting potential, on the action potentials, and on neuronal excitability measured as the frequency of action potential firing.

 

 

 

 

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