Start Services Company Profile Publications Jobs Customers Contact

vivacell_graurotbuttonklein  Recent news

September 2016

Cooperation with Dhofar University (Sultanate of Oman)


May 2016

We were awarded the Stifterverband's "Innovative through Research" for our research activities.


April 2016

New Version of SimDerma including 30 important dermato-cosmetic parameters.

Read more here.


November 2015:

New Services in neurotoxicity and neuroprotection

Read more here.


October 2015:

SimDerma - new screening platform for cosmetic ingredients.


Read more here.


Services in Oral Care.

Read more here.


September 2015:

Please have a look at our new services in miRNA research.

Read more here.



New publications by VivaCell:


"Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary

in J Neuroinflamm. 2016 Jan


"Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia
Through Nrf2-Dependent Mechanisms."

in Mol Neurobiol. 2015 Nov


"microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia."

in J Neurochem, 2015 Sep


"Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes."
in Int Immunopharmacol. 2014 Jun

"Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia."
Neuroscience. 2014 Jan 28



Read more news...



vivacell_graurotbuttonklein  Opinions from our customers:


Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):


"During our well going cooperation over several years, we learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."  



Read more



Phytodrugs / Nutraceuticals
Cancer / Oncology
Recent Publications


We are awarded for our R&D activities by the Stifterverband:






We are proud members of:









VivaCell Quality-Certificate:




Read more ...

Publications - Cancer/Oncology




Denbinobin inhibits nuclear factor-kappaB and induces apoptosis via reactive oxygen species generation in human leukemic cells.

Sánchez-Duffhues G, Calzado MA, de Vinuesa AG, Appendino G, Fiebich BL, Loock U, Lefarth-Risse A, Krohn K, Muñoz E.

Biochem Pharmacol. 2009 Apr 15;77(8):1401-9. Epub 2009 Jan 21.




Aiello A, Fatorusso E, Luciano P, Macho A, Menna M, Muñoz E. Antitumoral effects of two novel unique naturally occurring terpene quinones isolated from the Mediterranean ascidian Aplidium Conicum. J.Med-Chem. 2005 In press.


Pajonk F, Scholber J, Fiebich B. Hypericin-an inhibitor of proteasome function. Cancer Chemother Pharmacol. 2005 May;55(5):439-46. Epub 2005 Jan 26.




Macho A, Blanco-Molina M, Spagliardi P, Appendino G, Bremner P, Heinrich M, Fiebich BL, Muñoz E. Identification of Ca2+ Ionophoretic and Apoptotic Daucanes from Giant Fennel (Ferula communis L.). Biochem. Pharmacol. 2004 Sep 1;68(5):875-83.


2003 and before


Sancho R, de la Vega L, Appendino G, Di Marzo V, Macho A, Munoz E. The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway. Br J Pharmacol. 2003 Nov;140(6):1035-44. Epub 2003 Oct 6.


Macho A, Sancho R, Minassi A, Appendino G, Lawen A, Munoz E. Involvement of reactive oxygen species in capsaicinoid-induced apoptosis in transformed cells. Free Radic Res. 2003 Jun;37(6):611-9.


Macho A, Lucena C, Sancho R, Daddario N, Minassi A, Munoz E, Appendino G. Nonpungent capsaicinoids from sweet pepper synthesis and evaluation of the chemopreventive and anticancer potential. Eur J Nutr. 2003 Jan;42(1):2-9.


Blanco-Molina M, Tron GC, Macho A, Lucena C, Calzado MA, Munoz E, Appendino G. Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway. Chem Biol. 2001 Aug;8(8):767-78.


Gajate C, Santos-Beneit AM, Macho A, Lazaro MC, Hernandez de Rojas A, Modolell M, Muñoz E, Mollinedo F. Involvement of mitochondria and caspase-3 in ET-18-OCH3 induced apoptosis of human leukemic cells. Int. J. Cancer 2000 86, 208-218





       Sprache         Language          Idioma