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vivacell_graurotbuttonklein  Recent news

September 2016

Cooperation with Dhofar University (Sultanate of Oman)

 

May 2016

We were awarded the Stifterverband's "Innovative through Research" for our research activities.

 

April 2016

New Version of SimDerma including 30 important dermato-cosmetic parameters.

Read more here.

 

November 2015:

New Services in neurotoxicity and neuroprotection

Read more here.

 

October 2015:

SimDerma - new screening platform for cosmetic ingredients.

simderma_werbefoto

Read more here.

 

Services in Oral Care.

Read more here.

 

September 2015:

Please have a look at our new services in miRNA research.

Read more here.

 


 

New publications by VivaCell:

 

"Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary
microglia."

in J Neuroinflamm. 2016 Jan

 

"Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia
Through Nrf2-Dependent Mechanisms."

in Mol Neurobiol. 2015 Nov

 

"microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia."

in J Neurochem, 2015 Sep

 

"Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes."
in Int Immunopharmacol. 2014 Jun

"Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia."
Neuroscience. 2014 Jan 28

 

 

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vivacell_graurotbuttonklein  Opinions from our customers:

p-pascoe-naturmedizin

Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):

:

"During our well going cooperation over several years, we learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."  

 

 

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opinions...

 

 

Phytodrug / Nutraceuticals
Immunomodulation
Cardiovascular inflammation
Oncology / Angiogenesis
Oral care
Central Nervous System
Microglia activation studies
Electrophysiological. Meas.
Dermatology / Cosmetics
Muscle
HIV-1 / AIDS
Diabetes
ADME
Permeability Studies
Toxicology
Urinary / Prostata
Animal health
Additional Services
Quality Certificate
SimDerma / Cosmetics
Neurotox testing / Protection
miRNA
Services in Oral Care

 

We are awarded for our R&D activities by the Stifterverband:

 

forschung_und_entwicklung_2016_web

 

 


 

We are proud members of:

 

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    koop-phyto-logo

ga 

 

logo_bpl-rgb_klein-web

 


 

VivaCell Quality-Certificate:

 

vivacellqualitycertificateenglish

 

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Services in Oral Care

 

VivaCell is combining the latest know-how on cellular and molecular biology and best expertise with focus on oral care, cosmetics, immunology, CNS, nutraceuticals and natural products.

 

Please consider our Services in Oral Care Flyer (PDF, 7 pages).

 

VivaCell provides the complete range of project development from basic R&D up to pre-clinical research (GLP) in one hand.

 

Our clients have the unique possibility to collect all relevant research data from one single source.

 

• VivaCell’s expertise has been demonstrated in a substantial number of research projects and scientific publications. We have a successful track record over 10 years in oral health care product research and development

Services in Oral Care

• Oral care products are mostly used to prevent the oral cavity from caries, gingivitis and periodontitis.
• Gingivitis is caused by gum accumulating bacteria and ends up in red, swollen and bleeding inflammation of the gum. Rarely it caused by injuring the gums from over-vigorous brushing.

• The daily use of selectively enriched oral care products like toothpaste or mouth rinses is the most effiective way to prevent gingivitis.

• VivaCell offers highly specialised and reliable models for testing oral care products (tooth paste, mouth wash etc.) for their potential to prevent or treat gingivitis.

• The models are used for testing marketed products as well as for the identification of new active principles and development of new products.

• VivaCell has a well established cooperation in this field with leading oral health care companies.

 

 

Services in Oral Health Care (in vitro)

 

VivaCell offers the full service to assess prophylactic and acute therapeutic effects of oral care products All cellular models may be used for testing single chemical identities or diverse galenic formulations. We offer the use of special filter application to assess the effects of final formulations- simulating a real live application with prophylactic short time or acute treatment protocols. VivaCells provides:

• Human primary cultures: with monocytes, gingival and periodontal ligament fibroblasts and keratinocytes to determine all relevant inflammation parameters linked to gingivitis and periodontitis (prostaglandins, cytokines, NF-kappaB, free radicals, etc.).

• Capsaicin and menthol receptors (TPRV-1 and CMR1) heterologous transfected cells (artificial tongue) suitable to test new, topically applied analgesic compounds in oral care.

• Epigenetics: miRNA, DNA methylation, HDACs

• Cell proliferation and cell cycle analysis: MTT, Alamar Blue, ATP, FACS

• Phagocytosis: fluorescent beads by FACS

• Lectin binding assay

 

Services in Oral Health Care (in vitro)

 

VivaCell furthermore provides:

• Wound healing and chemotaxis: cell migration by scratch assay or OrisTM Cell Migration Assay, chemotaxis by Boyden chamber, real-time wound healing assays

• Fibroblast cell line transfected with NF-kappaB promoter (luciferase assay)

• Intracellular signalling: kinases (MAPKs, Akt, PI3J, GSK; PKC etc.) by Western blot/ELISA; transcription factors by luciferase assay (AP-1, CREB etc.). intracellular calcium by FACS or microscope

• MMPs and TIMPs

• Immunohistochemistry and histopathology, video- microscopy, immunfluorescence, 3D-modelling

• Mitochondrial function: respirometry, mitochondrial membrane potential, ATP levels, ROS, anti-oxidant enzymes etc.

• in vivo model of mucositis: X-Ray-induced mucositis and chemotherapy-induced mucositis, (clinical, histochemistry and immunochemistry)

• The capacity to develop new models according the requirements of our costumer.

Tissue models In addition to various cellular models, VivaCell offers highly specialised tissue models to simulate the in vivo situation. Tissue models may be used to test single compounds as well as galenic formulations.

• Gingival epithelial and buccal epithelial tissue

• Effects on human gingival fibroblast/ human keratinocytes co-cultures/3D culture (all parameters)

 

Determination of transepithelial electrical resistance By determination of the transepethelial electrical resistance, we offer to study the effects of compounds and galenic formulations on tight junctions.


Determination of inflammatory parameters in gingival samples from clinical studies

 

We offer the determination of inflammatory parameters PGE2, IL-1, IL-8 and other cytokines, MMPs, free radicals (isoprostane) in various biological materials or samples from clinical studies. Services in Oral Health Care hu-gingival fibroblasts hu-keratinocytes

Anti-bacterial activity (in cooperation)

• Haemophilus actinomycetemcomitans (aerob)

• Streptoccocus mutans

• Lactobacillus

• Actinobacillus actinomycetemcomitans (anaerob)

• Porphyromonas gingivalis (anaerob)

• Prevotella intermedia (anaerob)

Safety studies (in cooperation, GLP and non-GLP)

• Cytotoxicity

• Genetic and Mutagenic Toxicology

• Corrosion and Skin Irritation

• Skin Penetration

• Bioavailability Services in Oral Health Care

 

 

 

 

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