Start Services Company Profile Publications Jobs Customers Contact

vivacell_graurotbuttonklein  Recent news

September 2016

Cooperation with Dhofar University (Sultanate of Oman)


May 2016

We were awarded the Stifterverband's "Innovative through Research" for our research activities.


April 2016

New Version of SimDerma including 30 important dermato-cosmetic parameters.

Read more here.


November 2015:

New Services in neurotoxicity and neuroprotection

Read more here.


October 2015:

SimDerma - new screening platform for cosmetic ingredients.


Read more here.


Services in Oral Care.

Read more here.


September 2015:

Please have a look at our new services in miRNA research.

Read more here.



New publications by VivaCell:


"Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary

in J Neuroinflamm. 2016 Jan


"Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia
Through Nrf2-Dependent Mechanisms."

in Mol Neurobiol. 2015 Nov


"microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia."

in J Neurochem, 2015 Sep


"Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes."
in Int Immunopharmacol. 2014 Jun

"Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia."
Neuroscience. 2014 Jan 28



Read more news...



vivacell_graurotbuttonklein  Opinions from our customers:


Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):


"During our well going cooperation over several years, we learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."  



Read more



Phytodrugs / Nutraceuticals
Cancer / Oncology
Recent Publications


We are awarded for our R&D activities by the Stifterverband:






We are proud members of:









VivaCell Quality-Certificate:




Read more ...

Publications - Immunology / Inflammation / AIDS



Mousavizadeh K, Stratz T, Mueller W, Fiebich BL. 5-HT3 receptor antagonist for the treatment of tendinopathy. Nat Clin Pract Rheumatol. 2008 Jun;4(6):E4. No abstract available.


Stratz C, Trenk D, Bhatia HS, Valina C, Neumann FJ, Fiebich BL. Identification of 5-HT3 receptors on human platelets: Increased surface immunoreactivity after activation with adenosine diphosphate (ADP) and thrombin receptor-activating peptide (TRAP). Thromb Haemost. 2008 Apr;99(4):784-6.




Seidel MF, Fiebich BL, Ulrich-Merzenich G, Candelario-Jalil E, Koch FW, Vetter H. Serotonin mediates PGE(2) overexpression through 5-HT(2A) and 5-HT (3) receptor subtypes in serum-free tissue culture of macrophage-like synovial cells. Rheumatol Int. 2008 Mar 27


Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz ML, Renner F, Fiebich BL, Munoz E, Ben-Neriah Y, Mechoulam R. Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation. Mol Pharmacol. 2007 Dec;72(6):1657-64. Epub 2007 Sep 25.


2005 and before


Marquez N, Sancho R, Bedoya LM, Alcami J, Lopez-Perez JL, Feliciano AS, Fiebich BL, Munoz E. Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway. Antiviral Res. 2005 Jun;66(2-3):137-45.


Vega LD, Munoz E, Calzado MA, Lieb K, Candelario-Jalil E, Gschaidmeir H, Farber L, Mueller W, Stratz T, Fiebich BL. The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochem Pharmacol. 2005 May 26.


Fiebich BL, Akundi RS, Lieb K, Candelario-Jalil E, Gmeiner D, Haus U, Muller W, Stratz T, Munoz E. (2004) Antiinflammatory effects of 5-HT3 receptor antagonists in lipopolysaccharide- stimulated primary human monocytes. Scand J Rheumatol Suppl. 2004:28-32.


Marquez N, Sancho R, Ballero M, Bremner P, Appendino G, Fiebich BL, Heinrich M, Munoz E. Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT. Planta Med. 2004 Nov;70(11):1016-21.


Sancho R, Macho A, de La Vega L, Calzado MA, Fiebich BL, Appendino G, Munoz E. (2004). Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappaB, NFAT, and activator protein 1 signaling pathways. J Immunol;172:2341-51.


Sancho R, Medarde M, Sanchez-Palomino S, Madrigal BM, Alcami J, Munoz E, San Feliciano A. Anti-HIV activity of some synthetic lignanolides and intermediates. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4483-6.


Sancho R, Marquez N, Gomez-Gonzalo M, Calzado MA, Bettoni G, Coiras MT, Alcami J, Lopez-Cabrera M, Appendino G, Munoz E. Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway. J Biol Chem. 2004 Sep 3;279(36):37349-59.


Calzado MA, Sancho R, Muñoz E. HIV-1 Tat increases the expression of Cleavage and Polyadenylation Specificity Factor 73 kDa subunit modulating cellular and viral expression. J. Virology 2004 78; 6846-54


Marquez N, Sancho R, Macho A, Calzado MA, Fiebich BL, Munoz E. Caffeic acid phenethylester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors. J Pharmacol Exp Ther. 2004 308:993-1001.


Norgauer J, Ibig Y, Gmeiner D, Herouy Y, Fiebich BL. Prostaglandin E2 synthesis in human monocyte-derived dendritic cells. Int J Mol Med. 2003 Jul;12(1):83-6.


Ulbrich H, Fiebich B, Dannhardt G. Cyclooxygenase-1/2 (COX-1/COX-2) and 5-lipoxygenase (5-LOX) inhibitors of the 6,7-diaryl-2,3-1H-dihydropyrrolizine type. Eur J Med Chem. 2002 Dec;37(12):953-9.


Sancho R, Lucena C, Macho A, Calzado MA, Blanco-Molina M, Minassi A, Appendino G, Muñoz, E. Immunosuppressive activity of capsaicinoids. Capsiate derived from sweet peppers inhibits NF-B activation and is a potent anti-inflammatory compound in vivo. Eur. J. Immunol. 2002 32, 1753-1763


Fiebich BL, Heinrich M, Hiller K.O., Kammerer N. Inhibition of TNF-a synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69. Phytomedicine 2001 8, 28-30.


Dannhardt G, Kiefer W, Krämer G, Maehrlein S, Nowe U, Fiebich B. The pyrroly moiety as a template for COX-1/COX-2 inhibitors. Eur. J. Med. Chem. 2000 35, 499-510.





       Sprache         Language          Idioma