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vivacell_graurotbuttonklein  Recent news

September 2016

Cooperation with Dhofar University (Sultanate of Oman)

 

May 2016

We were awarded the Stifterverband's "Innovative through Research" for our research activities.

 

April 2016

New Version of SimDerma including 30 important dermato-cosmetic parameters.

Read more here.

 

November 2015:

New Services in neurotoxicity and neuroprotection

Read more here.

 

October 2015:

SimDerma - new screening platform for cosmetic ingredients.

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Read more here.

 

Services in Oral Care.

Read more here.

 

September 2015:

Please have a look at our new services in miRNA research.

Read more here.

 


 

New publications by VivaCell:

 

"Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary
microglia."

in J Neuroinflamm. 2016 Jan

 

"Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia
Through Nrf2-Dependent Mechanisms."

in Mol Neurobiol. 2015 Nov

 

"microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia."

in J Neurochem, 2015 Sep

 

"Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes."
in Int Immunopharmacol. 2014 Jun

"Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia."
Neuroscience. 2014 Jan 28

 

 

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vivacell_graurotbuttonklein  Opinions from our customers:

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Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):

:

"During our well going cooperation over several years, we learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."  

 

 

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opinions...

 

 

Phytodrug / Nutraceuticals
Immunomodulation
Cardiovascular inflammation
Oncology / Angiogenesis
Oral care
Central Nervous System
Microglia activation studies
Electrophysiological. Meas.
Dermatology / Cosmetics
Muscle
HIV-1 / AIDS
Diabetes
ADME
Permeability Studies
Toxicology
Urinary / Prostata
Animal health
Additional Services
Quality Certificate
SimDerma / Cosmetics
Neurotox testing / Protection
miRNA
Services in Oral Care

 

We are awarded for our R&D activities by the Stifterverband:

 

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We are proud members of:

 

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    koop-phyto-logo

ga 

 

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VivaCell Quality-Certificate:

 

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IMMUNOMODULATION 

 

antikoerper

 

At VivaCell, we offer a wide portfolio of protocols to evaluate the natural and specific immune response in isolated human and murine lymphoid cells and also in transformed cell lines. In addition, animal models mimicking human pathologies are also offered. Thus, our “in vivo”and “in vitro”models are suitable for preclinical validation of anti-inflammatory and immunomodulatory compounds.

 

In vitro models

· Primary human monocytes, T-/B-lymphocytes, neutrophils, natural killer cells, dendritic cells fibroblasts, keratocytes, melanocytes, endothelial cells, chondrocytes etc.

· Murine thymocytes and primed T cells from spleen and lymphatic nodes of antigen- stimulated mice.

· Cell lines (transformed T-cell lines, B-cell lines, macrophage cell lines etc).

 

In vivo models
- Inflammatory Bowel Disease (IBD). A model for intestinal inflammation in swiss mice comparable to Crohn’s disease and colon ulcerative diseases. The parameters to measure are morphological and histopathological.


· Septic shock. Induced by LPS in BALB/c mice and the parameters to measure are survival and measurement of IL-1, TNFa, and IL-6 in serum. Transcription factors are also measured in isolated spleen cells of treated mice.
· Collagen-induced Arthritis (CIA). Morphological and histopathological criteria and phenotypical analysis of inflammatory infiltration in affected joints. Cytokine levels in serum.
· Experimental Autoimmune Encephalitis
· Skin allograft rejection
· Delayed-type hypersensitive reaction (murine model for human allergic contact dermatitis)
· Murine model of intestinal ischiemia-reperfusion
· In vivo activation of T and B cells (BrdU staining)
· In vivo measurement of phagocyte function.

 

For list of parameters, please contact us.

 

 

 

 

 

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