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vivacell_graurotbuttonklein  Recent news

September 2016

Cooperation with Dhofar University (Sultanate of Oman)

 

May 2016

We were awarded the Stifterverband's "Innovative through Research" for our research activities.

 

April 2016

New Version of SimDerma including 30 important dermato-cosmetic parameters.

Read more here.

 

November 2015:

New Services in neurotoxicity and neuroprotection

Read more here.

 

October 2015:

SimDerma - new screening platform for cosmetic ingredients.

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Read more here.

 

Services in Oral Care.

Read more here.

 

September 2015:

Please have a look at our new services in miRNA research.

Read more here.

 


 

New publications by VivaCell:

 

"Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary
microglia."

in J Neuroinflamm. 2016 Jan

 

"Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia
Through Nrf2-Dependent Mechanisms."

in Mol Neurobiol. 2015 Nov

 

"microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia."

in J Neurochem, 2015 Sep

 

"Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes."
in Int Immunopharmacol. 2014 Jun

"Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia."
Neuroscience. 2014 Jan 28

 

 

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vivacell_graurotbuttonklein  Opinions from our customers:

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Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):

:

"During our well going cooperation over several years, we learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."  

 

 

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opinions...

 

 

Phytodrug / Nutraceuticals
Immunomodulation
Cardiovascular inflammation
Oncology / Angiogenesis
Oral care
Central Nervous System
Microglia activation studies
Electrophysiological. Meas.
Dermatology / Cosmetics
Muscle
HIV-1 / AIDS
Diabetes
ADME
Permeability Studies
Toxicology
Urinary / Prostata
Animal health
Additional Services
Quality Certificate
SimDerma / Cosmetics
Neurotox testing / Protection
miRNA
Services in Oral Care

 

We are awarded for our R&D activities by the Stifterverband:

 

forschung_und_entwicklung_2016_web

 

 


 

We are proud members of:

 

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    koop-phyto-logo

ga 

 

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VivaCell Quality-Certificate:

 

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Microglia activation studies

(Alzheimer, Parkinson, MS, stroke)

 nervensystem

 

Microglia play an important role in pathogenesis of several neurodegenerative diseases such as in Alzheimer’s disease in which they become activated, displaying both innate immune response and increased phagocytic activity.

 

A robust innate immune response occurs in association with Abeta containing plaques in brain of AD patients. This immune response is characterized by activation of various inflammatory parameters such as complement, increased secretion of several cytokines and chemokines, increased production of reactive oxygen and nitrogen species, and increased production of prostaglandin (PG) E2 (Cooper et al., 2000; El Khoury et al., 1996; Husemann et al., 2001; Lue et al., 2001, Shie et al., 2005), some combinations of which can be neurotoxic.

 

VivaCell offers in vitro assays studying the effects of drugs, compounds etc. on the activation of microglia:

 

- Primary microglia of rat and mouse

- Effects on microglia phagocytosis (Abeta phagocytosis)

- Effects on inflammatory parameters in microglia (cytokines, NO, prostaglandins, MMPs, ROS etc.)

- Chemotaxis/migration

- Proliferation

- Kinase pathways and transcription factors

- Organotypic cultures (neurons, astrocytes, microglia) with microglia knock down to study the role of microglia in neuroprotection

- Morphology and 3D Anaylsis of microglia in brain tissues (mouse, wildtpye or transgenics)

 

References: Publications on microglia activation see http://www.vivacell.de/CNS1.htm or contact fiebich@vivacell.de for pdf files.

 

 

 

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