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vivacell_graurotbuttonklein  Recent news

September 2016

Cooperation with Dhofar University (Sultanate of Oman)

 

May 2016

We were awarded the Stifterverband's "Innovative through Research" for our research activities.

 

April 2016

New Version of SimDerma including 30 important dermato-cosmetic parameters.

Read more here.

 

November 2015:

New Services in neurotoxicity and neuroprotection

Read more here.

 

October 2015:

SimDerma - new screening platform for cosmetic ingredients.

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Read more here.

 

Services in Oral Care.

Read more here.

 

September 2015:

Please have a look at our new services in miRNA research.

Read more here.

 


 

New publications by VivaCell:

 

"Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary
microglia."

in J Neuroinflamm. 2016 Jan

 

"Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia
Through Nrf2-Dependent Mechanisms."

in Mol Neurobiol. 2015 Nov

 

"microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia."

in J Neurochem, 2015 Sep

 

"Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes."
in Int Immunopharmacol. 2014 Jun

"Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia."
Neuroscience. 2014 Jan 28

 

 

Read more news...

 

 

vivacell_graurotbuttonklein  Opinions from our customers:

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Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):

:

"During our well going cooperation over several years, we learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."  

 

 

Read more
opinions...

 

 

Phytodrug / Nutraceuticals
Immunomodulation
Cardiovascular inflammation
Oncology / Angiogenesis
Oral care
Central Nervous System
Microglia activation studies
Electrophysiological. Meas.
Dermatology / Cosmetics
Muscle
HIV-1 / AIDS
Diabetes
ADME
Permeability Studies
Toxicology
Urinary / Prostata
Animal health
Additional Services
Quality Certificate
SimDerma / Cosmetics
Neurotox testing / Protection
miRNA
Services in Oral Care

 

We are awarded for our R&D activities by the Stifterverband:

 

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We are proud members of:

 

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    koop-phyto-logo

ga 

 

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VivaCell Quality-Certificate:

 

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Read more ...

 

PHYTODRUG /

NUTRACEUTICALS

 pflanzen_wirkstoffe

 

VivaCell Ltd. has broad experience and expertise in phytodrug research with a variety of natural products used as phytodrugs or nutraceuticals for several indications (e.g. St. John's wort (Hypericum), Devils Claw (Harpagophytum), fever few (Tanacetum), butterbur (Petasites), mistletoe (Viscum) and many others).


Our natural product research involves:


· Rapid screening of plant extracts and fractions
· Identification of phytodrug targets
· Identification of molecular mechanisms affected by phytodrugs
· Fractionation
· Phytochemistry
· Identification and purification of active principles
· Functional studies for standardization and quality procedures for
extracts, where the function is not related to the lead compounds


In vitro models:

In vitro testing methods for phytodrugs and nutraceuticals include all primary cells and cell lines described on the following pages. They will be chosen depending on the indication of the phytodrugs/plant extract and to the needs of the customers in individual and flexible protocols.


Parameters:

Parameters will be chosen according to the needs of the customers and the indication of the phytodrug/nutraceutical.


Functional studies of natural products:

Standardisation of anthroposophic and phytotherapeutic extracts has been bedevilled by major problems such as variable composition of the extract, lack of knowledge of active component(s) and mechanism of action, to cite a few.

Particularly with regard to herbal extracts information's about the
precise nature of the effective components are still lacking. In view of standardization procedures for extracts additional information on the "efficacy-level" would be desirable.


Therefore we offer functional studies with micro-arrays to test the
efficacy on the gene-expression level. In addition, detection of
specific and defined parameters can be carried out with different
techniques (e.g. ELISA, Multiplex-PCR).

 

 

 

 

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