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vivacell_graurotbuttonklein  Recent news

September 2016

Cooperation with Dhofar University (Sultanate of Oman)


May 2016

We were awarded the Stifterverband's "Innovative through Research" for our research activities.


April 2016

New Version of SimDerma including 30 important dermato-cosmetic parameters.

Read more here.


November 2015:

New Services in neurotoxicity and neuroprotection

Read more here.


October 2015:

SimDerma - new screening platform for cosmetic ingredients.


Read more here.


Services in Oral Care.

Read more here.


September 2015:

Please have a look at our new services in miRNA research.

Read more here.



New publications by VivaCell:


"Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary

in J Neuroinflamm. 2016 Jan


"Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia
Through Nrf2-Dependent Mechanisms."

in Mol Neurobiol. 2015 Nov


"microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia."

in J Neurochem, 2015 Sep


"Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes."
in Int Immunopharmacol. 2014 Jun

"Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia."
Neuroscience. 2014 Jan 28



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vivacell_graurotbuttonklein  Opinions from our customers:


Dr. G. Weiss (PASCOE pharmazeutische Praeparate GmbH):


"During our well going cooperation over several years, we learned to appreciate VivaCell as a reliable and competent co-operation partner in pre-clinical research. Therefore we are looking forward to continue our successful partnership."  



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Phytodrugs / Nutraceuticals
Cancer / Oncology
Recent Publications


We are awarded for our R&D activities by the Stifterverband:






We are proud members of:









VivaCell Quality-Certificate:




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Publications - Phytodrugs / Nutraceuticals


Pharmacological studies in an herbal drug combination of St. John's Wort (Hypericum perforatum) and passion flower (Passiflora incarnata): in vitro and in vivo evidence of synergy between Hypericum and Passiflora in antidepressant pharmacological models.

Fiebich BL, Knörle R, Appel K, Kammler T, Weiss G.

Fitoterapia. 2011 Apr;82(3):474-80. Epub 2010 Dec 24.


Minocycline reduces prostaglandin E synthase expression and 8-isoprostane formation in LPS-activated primary rat microglia.

Silva Bastos LF, Pinheiro de Oliveira AC, Magnus Schlachetzki JC, Fiebich BL.

Immunopharmacol Immunotoxicol. 2011 Jan 12. [Epub ahead of print]


Pharmacological studies in an herbal drug combination of St. John's Wort (Hypericum perforatum) and passion flower (Passiflora incarnata): in vitro and in vivo evidence of synergy between Hypericum and Passiflora in antidepressant pharmacological models.

Fiebich BL, Knörle R, Appel K, Kammler T, Weiss G.

Fitoterapia. 2011 Apr;82(3):474-80. Epub 2010 Dec 24.


Modulation of the gamma-aminobutyric acid (GABA) system by Passiflora incarnata L.

Appel K, Rose T, Fiebich B, Kammler T, Hoffmann C, Weiss G.

Phytother Res. 2010 Nov 19. doi: 10.1002/ptr.3352. [Epub ahead of print]


Traditionally used Thai medicinal plants: in vitro anti-inflammatory, anticancer and antioxidant activities.

Siriwatanametanon N, Fiebich BL, Efferth T, Prieto JM, Heinrich M.

J Ethnopharmacol. 2010 Jul 20;130(2):196-207. Epub 2010 May 8.


Endogenous N-acyl-dopamines induce COX-2 expression in brain endothelial cells by stabilizing mRNA through a p38 dependent pathway.

Navarrete CM, Pérez M, de Vinuesa AG, Collado JA, Fiebich BL, Calzado MA, Muñoz E.

Biochem Pharmacol. 2010 Jun 15;79(12):1805-14. Epub 2010 Mar 3.


Synthesis and biological evaluation of 12-aminoacylphorboids.

Pagani A, Navarrete C, Fiebich BL, Muñoz E, Appendino G.

J Nat Prod. 2010 Mar 26;73(3):447-51.


Opposite effects of anandamide and N-arachidonoyl dopamine in the regulation of prostaglandin E and 8-iso-PGF formation in primary glial cells.

Navarrete CM, Fiebich BL, de Vinuesa AG, Hess S, de Oliveira AC, Candelario-Jalil E, Caballero FJ, Calzado MA, Muñoz E.J Neurochem. 2009 Apr;109(2):452-64. Epub 2009 Feb 7.

Click here for the abstract of this publication.



Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells

Click below for the link in "Journal of Neuroinflammation":




Bhatia HS, Candelario-Jalil E, de Oliveira AC, Olajide OA, Martínez-Sánchez G, Fiebich BL. Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells. Arch Biochem Biophys. 2008 Sep 15;477(2):253-8. Epub 2008 Jun 28.


Moussaieff A, Shein NA, Tsenter J, Grigoriadis S, Simeonidou C, Alexandrovich AG, Trembovler V, Ben-Neriah Y, Schmitz ML, Fiebich BL, Munoz E, Mechoulam R, Shohami E. Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii. J Cereb Blood Flow Metab. 2008 Apr 16;




Candelario-Jalil E, de Oliveira AC, Gräf S, Bhatia HS, Hüll M, Muñoz E, Fiebich BL. Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia. J Neuroinflammation. 2007 Oct 10;4:25.


Appendino G, Ottino M, Marquez N, Bianchi F, Giana A, Ballero M, Sterner O, Fiebich BL, Munoz E. Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum. J Nat Prod. 2007 Apr;70(4):608-12.




Pajonk F, Riedisser A, Henke M, McBride WH, Fiebich B. The effects of tea extracts on proinflammatory signaling. BMC Med. 2006 Dec 1;4:28.

Fiebich BL, Valente P, Ferrer-Montiel A, Candelario-Jalil E, Menthe J, Luecker P. Effects of coffees before and after special treatment procedure on cell membrane potentials in stomach cells. Methods Find Exp Clin Pharmacol. 2006 Jul-Aug;28(6):369-72.


Candelario-Jalil E, Akundi RS, Bhatia HS, Lieb K, Appel K, Munoz E, Hull M, Fiebich BL. Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E(2) production. J Neuroimmunol. 2006 Mar 8;


Garita-Hernandez M, Calzado MA, Caballero FJ, Macho A, Munoz E, Meier B, Brattstrom A, Fiebich BL, Appel K. The Growth Inhibitory Activity of the Cimicifuga racemosa Extract Ze 450 is Mediated through Estrogen and Progesterone Receptors-Independent Pathways. Planta Med. 2006 Mar;72(4):317-23.


Fiebich BL, Candelario-Jalil E, Mantovani M, Heinzmann M, Akundi RS, Hull M, Knorle R, Schnierle P, Finkenzeller G, Aicher B. Modulation of catecholamine release from rat striatal slices by the fixed combination of aspirin, paracetamol and caffeine. Pharmacol Res. 2006 Mar 28;


Navarrete C, Sancho R, Caballero FJ, Pollastro F, Fiebich BL, Sterner O, Appendino G, Munoz E. Basiliolides, a class of tetracyclic C19 dilactones from Thapsia garganica, release Ca(2+) from the endoplasmic reticulum and regulate the activity of the transcription factors nuclear factor of activated T cells, nuclear factor-kappaB, and activator protein 1 in T lymphocytes. J Pharmacol Exp Ther. 2006 Oct;319(1):422-30. Epub 2006 Jul 13.


2005 and before


Pajonk F, Scholber J, Fiebich B. Hypericin-an inhibitor of proteasome function. Cancer Chemother Pharmacol. 2005 May;55(5):439-46.

Marquez N, Sancho R, Bedoya LM, Alcami J, Lopez-Perez JL, Feliciano AS, Fiebich BL, Munoz E. Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway. Antiviral Res. 2005 Jun;66(2-3):137-45. Epub 2005 Apr 20.


Garrido G, Blanco-Molina M, Sancho R, Macho A, Delgado R, Muñoz E. The Standard Aqueous Stem Bark Extract of Mangifera indica (Vimang) Inhibits T Cell Proliferation and TNF-induced Activation of Nuclear Transcription Factor NF-kB. Phytother Res. 2005 Mar;19(3):211-5.


Calzado MA, Schmid Ludi K, Fiebich BL, Ben-Neriah Y, Bacher S, Munoz E, Ballero M, Prosperini S, Appendino G, Schmitz ML. Inhibition of NF-kappaB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus.

Biochim Biophys Acta. 2005 Jun 7.


Fiebich BL, Grozdeva M, Hess S, Hull M, Danesch U, Bodensieck A, Bauer R. Petasites hybridus extracts in vitro inhibit COX-2 and PGE2 release by direct interaction with the enzyme and by preventing p42/44 MAP kinase activation in rat primary microglial cells.

Planta Med. 2005, 71:12-9.


Marquez N, Sancho R, Ballero M, Bremner P, Appendino G, Fiebich BL, Heinrich M, Munoz E. Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT. Planta Med. 2004. 70:1016-21.


Bremner P, Tang S, Birkmayer H, Fiebich BL, Munoz E, Marquez N, Rivera D, Heinrich M. Phenylpropanoid NF-kappaB inhibitors from Bupleurum fruticosum. Planta Med. 2004, 70: 914-8.


Appendino G, Bianchi F, Bader A, Campagnuolo C, Fattorusso E, Taglialatela-Scafati O, Blanco-Molina M, Macho A, Fiebich BL, Bremner P, Heinrich M, Ballero M, Muñoz E. (2004). Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin. J Nat Prod. 67:532-6.


Fiebich BL, Chrubasik S. Effects of an ethanolic salix extract on the release of selected inflammatory mediators in vitro. Phytomedicine. 2004 Feb;11(2-3):135-8.


Appendino G, Bianchi F, Bader A, Campagnuolo C, Fattorusso E, Taglialatela-Scafati O, Blanco-Molina M, Macho A, Fiebich BL, Bremner P, Heinrich M, Ballero M, Munoz E. Coumarins from Opopanax chironium. New Dihydrofuranocoumarins and Differential Induction of Apoptosis by Imperatorin and Heraclenin. J Nat Prod. 2004, 67:532-6.


Fiebich BL, Appel K. Anti-inflammatory effects of willow bark extract. Clin Pharmacol Ther. 2003 Jul;74(1):96; author reply 96-7.


Fiebich BL, Lieb K, Engels S, Heinrich M. Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells. J Neuroimmunol. 2002 Nov;132(1-2):18-24.


Chrubasik S, Pollak S, Fiebich B. Harpagophytum extracts. Clin Pharmacol Ther. 2002 Jan;71(1):104-5.


Fiebich BL, Heinrich M, Hiller KO, Kammerer N. Inhibition of TNF-alpha synthesis in LPSstimulated primary human monocytes by Harpagophytum extract SteiHap 69. Phytomedicine. 2001 Jan;8(1):28-30.


Fiebich BL, Hollig A, Lieb K. Inhibition of substance P-induced cytokine synthesis by St. John’s wort extracts. Pharmacopsychiatry. 2001 Jul;34 Suppl 1:S26-8.


Fiebich BL, Heinrich M, Langosch JM, Kammerer N, Lieb K. Antibacterial activity of hyperforin from St John’s wort. Lancet. 1999 Aug 28;354(9180):777.





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